What is another one of Leonardo da Vinci's most famous paintings called?

The correct answer is one of Leonardo da Vinci's most famous paintings, "The Last Supper." This mural, created in the late 15th century, depicts the moment Jesus announces that one of his disciples will betray him. It is renowned for its composition, emotional expression, and innovative use of perspective, which contributes to the dramatic portrayal of the event. The painting is not only a significant work in the history of art but also reflects the themes of betrayal, loyalty, and the human condition, making it a profound artistic achievement.

While the other options listed are also iconic works of art, they are by different artists. "The Creation of Adam" is a fresco by Michelangelo, "The School of Athens" is a fresco by Raphael, and "The Birth of Venus" is a painting by Sandro Botticelli. Each of these artworks holds immense importance in the history of art, but they do not belong to Leonardo da Vinci, hence highlighting "The Last Supper" as the relevant choice in this context.